Complementary and alternative medicine in reducing radiation-induced skin toxicity.
MouseRadiationSKH-hr1 hairlessFemaleTopical application to skinImmediately following each daily irradiation dose
Model: Ionising irradiation of skin at 10 Gy/day for 4 days
Both agents significantly reduced radiation-induced MCP1, KC and G-CSF and inhibited IL-1 alpha, MCP1 and VEGF. CWH significantly reduced erythema and blood vessel dilation at day 10, whereas Calendula officinalis did not and was associated with worse skin reactions than irradiation alone.
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