THERAPY DOSSIER · th-f52f31a66d81

Calendula officinalis (CO) and Ching Wan Hung (CWH)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01688479 ↗PHASE3completed

Randomized, Blinded Phase III Trial Comparing Calendula Officinalis Cream With Standard Aqueous Cream Essex for Treatment of Skin Reactions Caused by Postoperative Radiotherapy of Breast Cancer

Postoperative Radiotherapy Breast Cancer

Enrolment: 420 · Results not recorded

NCT04833998 ↗PHASE2unknown

Hydration Based on Thoitaine, Aloe Vera and Calendula, in the Prevention of Hand-Foot Syndrome in Patients Using Capecitabine: TACX Care Trial

Hand-foot Syndrome

Enrolment: 54 · Results not recorded

NCT05073172 ↗NAwithdrawn

A Randomized Intra-Patient Controlled Study of StrataXRT Versus Current Practice to Prevent and Treat Radiation Dermatitis

Breast Carcinoma · Head and Neck Carcinoma · Radiation-Induced Dermatitis

Enrolment: 0 · Results not recorded

NCT05810194 ↗Phase not recordedcompleted

Retrospective Cohort Study Comparing a Novel Silicone Gel Wound Dressing vs Standard of Care in the Treatment of Radiation Dermatitis

Radiation Dermatitis

Enrolment: 344 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24792319 ↗2014Mixed findings

Complementary and alternative medicine in reducing radiation-induced skin toxicity.

MouseRadiationSKH-hr1 hairlessFemaleTopical application to skinImmediately following each daily irradiation dose

Model: Ionising irradiation of skin at 10 Gy/day for 4 days

Both agents significantly reduced radiation-induced MCP1, KC and G-CSF and inhibited IL-1 alpha, MCP1 and VEGF. CWH significantly reduced erythema and blood vessel dilation at day 10, whereas Calendula officinalis did not and was associated with worse skin reactions than irradiation alone.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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