Augmentation of tendon healing with an injectable tendon hydrogel in a rat Achilles tendon model.
RatOtherWistarn = 36 rats, both Achilles tendons per animalInjection into the tendon injury siteAt the time of injury
Model: Bilateral full-thickness Achilles tendon injury approximately 5 mm long and 0.5 mm wide from the calcaneal insertion to the midsubstance
Ultimate failure load was significantly higher with hydrogel than saline at 4 weeks (74.8 plus or minus 11.6 N versus 58.4 plus or minus 14.2 N, p = 0.02), with no significant differences at 2 or 8 weeks and no differences in ultimate tensile stress or stiffness at any time point.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.