Cromolyn ameliorates acute and chronic injury in a rat lung transplant model.
RatIschaemia-reperfusionOther / unspecifiedWistar Kyoto donors into Fischer 344 recipientsMalen = 46 transplants performed; 35 long-term recipients (16 gastr…Subcutaneous injection plus aerosol inhalation150 mg/kg subcutaneously, plus aerosolised cromolyn at 50 m…First subcutaneous dose pre-operatively, then daily post-operatively; aerosol g…
Model: Orthotopic left lung allotransplantation with 5 hours cold plus 1 hour warm ischaemia, followed by weekly aspiration of gastric fluid for 8 weeks to induce obliterative bronchiolitis
No peri-operative mortality occurred in cromolyn-treated recipients versus 11 of 36 untreated recipients (p = 0.045). The mean fraction of airways affected by obliterative bronchiolitis fell from 0.456 plus or minus 0.068 to 0.108 plus or minus 0.030 (p < 0.001) and parenchymal fibrosis score from…
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