Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.
MouseTBIFluid percussionC57BL/6Malen = Ibuprofen n = 16, acetaminophen n = 9, vehicle n = 13, sham…IntraperitonealIbuprofen 60 mg/kg; acetaminophen 40 mg/kgSingle dose immediately after injury
Model: Midline fluid percussion injury producing diffuse traumatic brain injury, righting reflex time 6 to 10 minutes
Acute over-the-counter analgesic administration neither attenuated nor exacerbated injury-induced functional deficits, and cortical cytokine levels were affected by injury and time but not by treatment at 6 or 24 hours.
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