Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury.
MouseRadiationC57BL/6JFemalen = Three groups, non-irradiated control n = 30Oral gavage followed by drinking water400 mg/kg by gavage, then maintained at 2 mg/ml in drinking…Gavage about 1 hour before irradiation
Model: Single-dose thoracic gamma irradiation delivered at 1 Gy per minute
GSPs ameliorated both acute and late radiation-induced lung injury, scavenged hydroxyl radicals dose-dependently, suppressed TGF-beta1/Smad3/Snail signalling and modulated Th1/Th2 cytokines, while radiosensitising A549 tumour cells and protecting normal RLE-6TN alveolar epithelial cells.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.