THERAPY DOSSIER · th-3446efeb3878

Grape seed pro-anthocyanidins (GSPs)

Nutraceutical · Botanical extract (grape seed proanthocyanidins); not a discrete ChEMBL entity

Evidence & regulatory context

Mechanism: Botanical extract (grape seed proanthocyanidins); not a discrete ChEMBL entity
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04515004 ↗PHASE2terminated

Leucoselect Phytosome (grape seed proanthocyanidins) for Neoadjuvant Early-Stage Lung Cancer

Early Stage Lung Cancer

Enrolment: 6 · Results not recorded

NCT03030716 ↗NAcompleted

Condensed Proanthocyanidins From Grape Seed Extract and Iron Status

Iron Deficiency

Enrolment: 11 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24758615 ↗2014Reported benefit

Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury.

MouseRadiationC57BL/6JFemalen = Three groups, non-irradiated control n = 30Oral gavage followed by drinking water400 mg/kg by gavage, then maintained at 2 mg/ml in drinking…Gavage about 1 hour before irradiation

Model: Single-dose thoracic gamma irradiation delivered at 1 Gy per minute

GSPs ameliorated both acute and late radiation-induced lung injury, scavenged hydroxyl radicals dose-dependently, suppressed TGF-beta1/Smad3/Snail signalling and modulated Th1/Th2 cytokines, while radiosensitising A549 tumour cells and protecting normal RLE-6TN alveolar epithelial cells.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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