Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
MouseRadiationC3H in vivo; mouse embryo fibroblasts, human microvascular endothelial cells and SA-NH mouse sarcoma cells in vitroMaleInjection, specific route not stated in retrieved textMetformin 250 mg/kg; amifostine 400 mg/kg; captopril 200 mg…Metformin and combinations 24 hours after irradiation; amifostine and WR1065 po…
Model: Whole-body 7 Gy X-ray irradiation assessed by endogenous spleen colony assay; cells irradiated at 4 Gy
Metformin elevated in vitro survival 1.3 to 1.5-fold and gave a splenic protection factor of 1.8 when given 24 hours after 7 Gy. Combination with N-acetyl-cysteine, MESNA or captopril enhanced survival 2.6, 2.8 and 2.4-fold respectively, comparable with amifostine given 30 minutes before irradiatio…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.