Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation.
RatSpinal cord injuryCompressionSprague-DawleyMalen = 16 per group across three groups5,000 IU/kg30 minutes after injury
Model: Laminectomy at T8-T9 with vascular clip compression of the spinal cord
rhEPO markedly upregulated Nrf2 pathway components and significantly reduced locomotor deficit, spinal cord oedema and apoptosis at 72 hours after injury.
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