Effects of paroxetine on cutaneous wound healing in healthy and diabetic rats.
RatWoundSprague-DawleyMalen = 64 rats, 32 healthy and 32 diabetic, each subdivided into s…Intraperitoneal injection
Model: Full-thickness 4 mm dermal punch excisional wound on the back, in healthy rats and streptozotocin-induced diabetic rats
Fibroblast numbers were significantly higher at day 14 in paroxetine-treated healthy rats than saline controls (p = 0.04) and complete epithelialisation was seen at day 14 in that group, but no differences were seen in diabetic rats or in leukocyte, mononuclear cell and blood vessel counts.
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