Unique mechanisms of sheng yu decoction (sheng yu tang) on ischemic stroke mice revealed by an integrated neurofunctional and transcriptome analysis.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Oral1.0 g/kgAfter induction of ischaemic stroke
Model: Acute cerebral ischaemic stroke in mice
Sheng Yu Decoction extended lifespan compared with vehicle, in which over 80 per cent of mice died within 2 days, restored brain function, reduced cerebral infarction and oxidative stress and improved neurological deficits. It significantly altered 162 of 2081 ischaemia-induced probe sets.
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