Assessment of the effect of local application of amifostine on acute radiation-induced oral mucositis in guinea pigs.
Guinea pigRadiationn = 32 guinea pigs, 8 per group across four groupsTopical application to buccal mucosa for 30 min50 mg or 100 mg of amifostine per animal, delivered as 0.5…15 min before irradiation
Model: Single 30 Gy irradiation of bilateral buccal mucosa causing acute oral mucositis
Topical amifostine at 50 mg and 100 mg reduced macroscopic mucositis scores to 2.9 plus or minus 0.6 and 2.4 plus or minus 1.1 respectively versus 4.4 plus or minus 0.7 for saline plus radiotherapy, with no significant difference between the two doses. Histology and ICAM-1 expression showed corresp…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.