An in vivo study of composite microgels based on hyaluronic acid and gelatin for the reconstruction of surgically injured rat vocal folds.
RatWoundSprague-DawleyMalen = 108 ratsLocal injection into the vocal fold lamina propria25 microlitres per injection5 days after surgical injury
Model: Unilateral surgical vocal fold stripping
HA-Ge injection was biocompatible and produced significantly lower macrophage counts than saline at day 28 without inflammatory or rejection responses. Myofibroblast counts and elastin did not differ significantly between treatments, and collagen type I was higher in the HA-Ge and HA-bulk groups th…
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