THERAPY DOSSIER · th-e2a40f6d4208

Hyaluronic acid-gelatin (HA-Ge) composite microgel hydrogel

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24687141 ↗2014Mixed findings

An in vivo study of composite microgels based on hyaluronic acid and gelatin for the reconstruction of surgically injured rat vocal folds.

RatWoundSprague-DawleyMalen = 108 ratsLocal injection into the vocal fold lamina propria25 microlitres per injection5 days after surgical injury

Model: Unilateral surgical vocal fold stripping

HA-Ge injection was biocompatible and produced significantly lower macrophage counts than saline at day 28 without inflammatory or rejection responses. Myofibroblast counts and elastin did not differ significantly between treatments, and collagen type I was higher in the HA-Ge and HA-bulk groups th…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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