Adrenaline stimulates the proliferation and migration of mesenchymal stem cells towards the LPS-induced lung injury.
RatEndotoxin/LPSSprague-DawleyMaleAdrenaline 10 microM for in vitro stimulation of bone marro…
Model: Lipopolysaccharide-induced acute lung injury, with ex vivo lung cell and lung tissue co-culture models
Adrenaline at 10 microM enhanced mesenchymal stem cell proliferation through both alpha and beta adrenergic receptors and promoted migration towards lipopolysaccharide-injured lung cells and tissue. Adrenaline-stimulated cells reduced macrophage inflammation, probably through paracrine factors, and…
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