THERAPY DOSSIER · th-cc03de7e3825

Adrenaline-stimulated bone marrow-derived mesenchymal stem cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24684532 ↗2014Reported benefit

Adrenaline stimulates the proliferation and migration of mesenchymal stem cells towards the LPS-induced lung injury.

RatEndotoxin/LPSSprague-DawleyMaleAdrenaline 10 microM for in vitro stimulation of bone marro…

Model: Lipopolysaccharide-induced acute lung injury, with ex vivo lung cell and lung tissue co-culture models

Adrenaline at 10 microM enhanced mesenchymal stem cell proliferation through both alpha and beta adrenergic receptors and promoted migration towards lipopolysaccharide-injured lung cells and tissue. Adrenaline-stimulated cells reduced macrophage inflammation, probably through paracrine factors, and…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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