Acute insulin resistance mediated by advanced glycation endproducts in severely burned rats.
RatBurnUnspecifiedSprague-DawleyEarly after burn injury, before the second hyperglycaemic peak at 3 h
Model: Full-thickness burn covering 40 per cent of total body surface area
Burn injury produced two hyperglycaemic peaks at 0.5 h and 3 h, with acute insulin resistance at 3 h that correlated positively with mortality. Serum carboxymethyllysine rose within 1 h, preceding insulin resistance. Both sRAGE treatment and early glycaemic control with insulin alleviated postburn…
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