Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis.
MouseChemical/toxinBALB/cFemaleSubcutaneousPrior to and during the induction of colitis
Model: Dextran sulfate sodium in drinking water for 7 days causing acute colitis
Subcutaneous neutrophil elastase inhibitor reduced the severity of dextran sulfate sodium colitis, lowered the elevated neutrophil elastase activity in inflamed colon and decreased colonic IL-17 mRNA expression.
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