Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury.
MouseTBIWeight-drop / impact-accelerationC57BL/6 wild-type and TLR4 knockoutIntraperitoneal100 mg/kg (different concentrations tested)15 min after injury
Model: Weight-drop contusion traumatic brain injury; microglia and neuron co-culture with lipopolysaccharide stimulation in vitro
TLR4 protein peaked at 24 h after injury and TLR4 knockout mice showed less functional impairment, oedema and cytokine release. Curcumin at 100 mg/kg reduced TLR4-positive microglia and macrophages, inflammatory mediator release and neuronal apoptosis, and lowered TLR4, MyD88 and NF-kappaB levels,…
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