Therapeutic effect of sildenafil on blast-induced tinnitus and auditory impairment.
RatOtherSprague-DawleyMaleAfter blast exposure
Model: Three consecutive blast exposures at 22 psi causing tinnitus, auditory impairment and traumatic brain injury
Sildenafil did not prevent acute tinnitus onset or hearing impairment, but significantly suppressed high-frequency tinnitus from 3 to 6 weeks after blast exposure and reduced hearing impairment during the first week. Startle force was reduced relative to untreated blast-exposed rats, suggesting pos…
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