Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines.
MouseRadiationC57BL/6JFemalen = 50 mice across three groupsPre-treatment before irradiation
Model: Thoracic irradiation-induced pneumonitis
Genistein reduced acute inflammatory and fibrinoid exudation, suppressed the irradiation-induced rise in APE1 and NF-kappaB activity, and lowered TGF-beta1, IL-1beta, TNF-alpha and IL-6 in serum and bronchoalveolar lavage fluid (P<0.05).
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