Effect of lacosamide on structural damage and functional recovery after traumatic brain injury in rats.
RatTBIFluid percussionSprague-DawleyMaleIntraperitoneal30 mg/kg per dose, total daily dose 90 mg/kg/dayFirst dose 30 min after injury
Model: Moderate lateral fluid-percussion traumatic brain injury
Lacosamide had no protective effect on structural or functional outcome. Composite neuroscore recovery in the lacosamide group lagged behind the vehicle group at 15 days post-injury (P<0.05), with no differences in beam-walking, water maze, MRI or histology.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.