Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury--a morphological and functional comparison in rats.
RatSpinal cord injuryContusionSprague-DawleyIntraspinal injectionEarly (acute) or delayed transplantation after contusion injury
Model: Contusion spinal cord injury
Grafted cells survived to 7 days after injection but largely disappeared over the following 2 weeks. Both cell types provided tissue protection after early and delayed transplantation, but only acute mesenchymal stromal cell grafts improved treadmill locomotion and electrophysiological outcomes.
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