THERAPY DOSSIER · th-b17970e7f1ae

Bone marrow mesenchymal stromal cells and olfactory ensheathing cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03933072 ↗Injury indicationPHASE1/PHASE2unknown

Autologous Bulbar Olfactory Ensheathing Cells and Spinal Cord Bridging in Complete SCI

Spinal Cord Injury C5-Th10 · Spinal Cord Transection

Enrolment: 2 · Results not recorded

NCT01231893 ↗Injury indicationPHASE1unknown

Autologous Olfactory Ensheathing Cell Transplantation for Complete Spinal Cord Injury

Complete Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT07596563 ↗Injury indicationPHASE1not yet recruiting

Olfactory Cell Transplantation Plus Intensive Rehabilitation in Chronic Traumatic SCI

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT01327768 ↗PHASE1unknown

Intracerebral Implantation of Olfactory Ensheathing Cells in Old Stroke Patients

Middle Cerebral Artery Infarction · Ischaemic Stroke

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24635194 ↗2014Mixed findings

Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury--a morphological and functional comparison in rats.

RatSpinal cord injuryContusionSprague-DawleyIntraspinal injectionEarly (acute) or delayed transplantation after contusion injury

Model: Contusion spinal cord injury

Grafted cells survived to 7 days after injection but largely disappeared over the following 2 weeks. Both cell types provided tissue protection after early and delayed transplantation, but only acute mesenchymal stromal cell grafts improved treadmill locomotion and electrophysiological outcomes.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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