Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury.
RatTBIControlled cortical impactSprague-Dawleymalen = 55 rats subjected to TBI; histology in four groups of n = 6…intravenous, via the jugular veinG-CSF 300 microgram/kg in 500 microlitre sterile saline; hU…7 days after controlled cortical impact
Model: Moderate controlled cortical impact traumatic brain injury; craniectomy about 2.5 mm radius at +0.2 mm anterior and -0.2 mm lateral right of bregma, impact to fronto-parietal cortex at 6.0 m/s to 1.0 mm below dura, 150 ms dwell, impactor angled 15 degrees
Combined hUCB plus G-CSF robustly dampened neuroinflammation, enhanced endogenous neurogenesis, reduced hippocampal cell loss and produced long-lasting motor recovery to day 56. hUCB monotherapy gave intermediate benefit, while G-CSF monotherapy produced only partial and short-lived motor benefit t…
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