Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats.
RatEndotoxin/LPSSprague-DawleyBoth sexesn = 72 rats from six litters, 12 groups with n=6 per groupIntraperitoneal20 mg/kg, dissolved in 5% ethanol in saline5 min after lipopolysaccharide injection
Model: Systemic lipopolysaccharide (2 mg/kg intraperitoneal, serotype 055:B5) induced neonatal brain injury
Melatonin shortened the lipopolysaccharide-induced increase in righting reflex latency and limited the fall in wire-hanging latency, attenuated loss of O4 positive oligodendrocytes and axonal amyloid precursor protein accumulation, prevented the fall in mitochondrial complex I activity, and reduced…
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