Combined Bone Mesenchymal Stem Cell and Olfactory Ensheathing Cell Transplantation Promotes Neural Repair Associated With CNTF Expression in Traumatic Brain-Injured Rats.
RatTBIWeight-drop / impact-accelerationSprague-DawleyFemalen = 80 rats, 16 per group across five groups, with 8 per group…Transplantation into tissue surrounding the lesion epicentreAcute stage after traumatic brain injury
Model: Weight-drop traumatic brain injury
Single and combined transplantation significantly improved neurological severity scores. Grafted animals had more neurons and regenerated axons and fewer astrocytes at 14 days (P<0.05). Ciliary neurotrophic factor expression fell significantly in the co-transplantation group and the JAK/STAT pathwa…
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