Antioxidant and hepatoprotective effects of naringenin and its beta-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: a comparative study.
MouseChemical/toxinSwissMaleOral50 mg/kg body weightPre-treatment for 7 days before carbon tetrachloride on day 8
Model: Carbon tetrachloride-induced acute hepatic injury (1.0 mL/kg intraperitoneal)
Pre-treatment with free or beta-cyclodextrin formulated naringenin returned transaminases, malondialdehyde and antioxidant enzyme activities towards control values and reduced centrilobular necrosis, steatosis, fibrosis and ultrastructural damage.
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