Effect of Naringenin Supplementation on the Speed of Bone Fusion and the Concentration of Plasma Inflammatory Factors in Patients With Bone Fractures.
Bone Fractures
Enrolment: 70 · Results not recorded
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Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Bone Fractures
Enrolment: 70 · Results not recorded
Hepatitis C Virus · HCV Infection · Chronic HCV · Hepatitis C
Enrolment: 7 · Results not recorded
Safety Issues · Pharmacokinetics
Enrolment: 18 · Results not recorded
Energy Expenditure · Safety Issues · Glucose Metabolism
Enrolment: 1 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Carbon tetrachloride-induced acute hepatic injury (1.0 mL/kg intraperitoneal)
Pre-treatment with free or beta-cyclodextrin formulated naringenin returned transaminases, malondialdehyde and antioxidant enzyme activities towards control values and reduced centrilobular necrosis, steatosis, fibrosis and ultrastructural damage.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Carbon tetrachloride 10 mmol/kg intraperitoneally on day 8, with assessment 24 h later
Carbon tetrachloride raised malondialdehyde, depressed antioxidant enzymes and glutathione, and produced glomerular and tubular degeneration, collagen deposition and strong TGF-beta1 expression. Naringenin pre-treatment returned biochemical markers to control values, with histological and ultrastru…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Hypobaric hypoxia exposure in an altitude chamber causing brain injury
Naringenin and quercetin each reduced HIF-1alpha, VEGF, active caspase 3 and ubiquitin levels and ameliorated hypoxia-induced brain dysfunction and behavioural impairment.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.