Neuroprotective effects of autophagy induced by rapamycin in rat acute spinal cord injury model.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleInjected after induction of injury
Model: Acute spinal cord injury induced at the T10 level
Autophagy (rising LC3II and LC3I from 10 days) preceded apoptosis (caspase-3 rising from 21 days) after injury. Rapamycin treatment improved Gale scale hind limb grades relative to vehicle control and the authors concluded that rapamycin improved prognosis by inhibiting apoptosis.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.