Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin/p120ctn signaling.
MouseOtherC57BL/6MaleIntrathecalAcute injection on testing days after chronic constriction injury
Model: Chronic constriction injury of the sciatic nerve producing neuropathic pain
Chronic constriction injury rapidly decreased E-cadherin and membrane-associated p120 catenin in the spinal dorsal horn. GDNF upregulated E-cadherin-associated p120 catenin and attenuated thermal hyperalgesia, and both effects were inhibited by pre-treatment with the E-cadherin blocking antibody DE…
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