THERAPY DOSSIER · th-1917afa90fb0

Glial cell-derived neurotrophic factor (GDNF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00111982 ↗PHASE1/PHASE2completed

Extended Treatment With Liatermin (r-metHuGDNF) by Continuous Intraputaminal Infusion in Parkinson's Disease

Parkinson's Disease

Enrolment: 34 · Results not recorded

NCT00006488 ↗PHASE1completed

Continuously Infused Intracerebral r-metHuGDNF for Idiopathic Parkinson's Disease

Parkinson Disease

Enrolment not recorded · Results not recorded

NCT00115427 ↗PHASE1completed

Liatermin (r-metHuGDNF) by Bilateral Intraputaminal Infusion in Idiopathic Parkinson's Disease

Idiopathic Parkinson's Disease

Enrolment not recorded · Results not recorded

NCT01621581 ↗PHASE1completed

Convection Enhanced Delivery of AAV2-GDNF in Advanced Parkinson's Disease

Parkinson's Disease

Enrolment: 25 · Results not recorded

NCT04167540 ↗PHASE1active not recruiting

Open-Label Safety Study of AAV2-GDNF Gene Transfer in Parkinson's Disease

Parkinson's Disease

Enrolment: 11 · Results not recorded

NCT04680065 ↗PHASE1active not recruiting

Safety Study of AAV2-GDNF Gene Transfer in Multiple System Atrophy

Multiple System Atrophy

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24599758 ↗2014Reported benefit

Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin/p120ctn signaling.

MouseOtherC57BL/6MaleIntrathecalAcute injection on testing days after chronic constriction injury

Model: Chronic constriction injury of the sciatic nerve producing neuropathic pain

Chronic constriction injury rapidly decreased E-cadherin and membrane-associated p120 catenin in the spinal dorsal horn. GDNF upregulated E-cadherin-associated p120 catenin and attenuated thermal hyperalgesia, and both effects were inhibited by pre-treatment with the E-cadherin blocking antibody DE…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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