Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation.
MouseChemical/toxinC57BL/6Transplantation into the heartAfter induction of doxorubicin cardiomyopathy, with assessment 4 weeks later
Model: Chronic doxorubicin-induced cardiomyopathy
Four weeks after injury, embryonic stem cell and conditioned medium treated hearts showed significantly fewer apoptotic nuclei, reduced cytoplasmic vacuolisation, less fibrosis with downregulated MMP-9 activity, diminished oxidative stress and preserved antioxidant defences, with modulation of PTEN…
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