THERAPY DOSSIER · th-3ae2be5f15d7

Embryonic stem cells and embryonic stem cell conditioned medium

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02122159 ↗PHASE1/PHASE2withdrawn

Sub-retinal hESC-Derived RPE (MA09-hRPE) in Myopic Macular Degeneration

Myopic Macular Degeneration

Enrolment: 0 · Results not recorded

NCT02286089 ↗PHASE1/PHASE2active not recruiting

hESC-Derived RPE (OpRegen) Transplanted Subretinally in Advanced Dry AMD

Age-Related Macular Degeneration

Enrolment: 24 · Results not recorded

NCT03167203 ↗PHASE1/PHASE2enrolling by invitation

Safety Surveillance of hESC-Derived RPE Cell Therapy in Macular Degenerative Disease

Macular Degenerative Disease

Enrolment: 36 · Results not recorded

NCT03944239 ↗PHASE1active not recruiting

Subretinal Transplantation of Clinical hESC-Derived Retinal Pigment Epithelium in Retinitis Pigmentosa

Retinitis Pigmentosa

Enrolment: 25 · Results not recorded

NCT02463344 ↗NAcompleted

Long-Term Follow-up of Sub-retinal hESC-Derived RPE (MA09-hRPE) in Advanced Dry AMD

Age-Related Macular Degeneration

Enrolment: 11 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24594448 ↗2014Reported benefit

Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation.

MouseChemical/toxinC57BL/6Transplantation into the heartAfter induction of doxorubicin cardiomyopathy, with assessment 4 weeks later

Model: Chronic doxorubicin-induced cardiomyopathy

Four weeks after injury, embryonic stem cell and conditioned medium treated hearts showed significantly fewer apoptotic nuclei, reduced cytoplasmic vacuolisation, less fibrosis with downregulated MMP-9 activity, diminished oxidative stress and preserved antioxidant defences, with modulation of PTEN…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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