PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury.
RatSpinal cord injuryContusionSprague-Dawley (Harlan)femalen = n = 19 rats total: sham n = 3, vehicle n = 8, bpV n = 8intraperitoneal200 microgram/kg per injection in 0.9% saline, giving 400 m…immediately after injury, with a second dose at 2 hours post-injury
Model: Unilateral cervical hemicontusion spinal cord injury using the NYU/MASCIS impactor (2.5 mm tip, 10 g weight dropped from 12.5 mm) producing a moderate unilateral injury; anaesthesia ketamine 87 mg/kg with xylazine 12 mg/kg intraperitoneally
bpV(pic) significantly increased spared white matter (30%, p < 0.01) and Luxol Fast Blue myelin area rostrally (0.64 +/- 0.02 versus vehicle 0.56 +/- 0.01, p < 0.05) and at the epicentre (0.54 +/- 0.03 versus vehicle 0.42 +/- 0.03, p < 0.05). Ventrolateral funiculus oligodendrocyte density rose to…
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