Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.
RatTBIWeight-drop / impact-accelerationSprague-DawleyTransplantation into the regions surrounding the injured brain siteImmediately after the weight-drop injury
Model: Free weight-drop traumatic brain injury
Transplanted olfactory ensheathing cells survived and migrated around the injury site, significantly improved neurological severity scores, increased GAP-43 immunopositive fibres and synaptophysin-positive vesicles and reduced apoptotic cell numbers, with significant downregulation of Bad (all p <…
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