Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other · TBI · Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 4
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Evaluation of the Possibility of Induction of Functional Axon Regeneration in Patients With Complete Spinal Cord Injuries Using Autologous Bulbar Olfactory Ensheathing Cells and Techniques of Bridging of the Spinal Cord.
Spinal Cord Injury at C5-Th10 Level With Complete Lesion · Spinal Cord Transection
Enrolment: 2 · Results not recorded
Safety, Feasibility, Efficacy of Olfactory Cell Transplantation Therapy Combined With Intensive Exercise Rehabilitation to Repair Chronic Traumatic Spinal Cord Injury.
Spinal Cord Injury · Neurological Conditions · Rehabilitation Exercise
Enrolment: 30 · Results not recorded
Transplantation of Autologous Olfactory Ensheathing Cells for Treatment of Complete Human Spinal Cord Injuries- a Phase I Clinical Trial.
Complete Spinal Cord Injuries
Enrolment: 10 · Results not recorded
Evaluation of Safety, Feasibility and Treatment Potential for Old Stroke Patients Using Intracerebral Implantation of Olfactory Ensheathing Cells
Infarction, Middle Cerebral Artery · Ischemic Stroke, · Stroke With Hemiparesis, · Thromboembolic Stroke.
Enrolment: 6 · Results not recorded
Preclinical evidence 7
2 studies reported at therapy level; 7 evidence entries itemised.
RatOtherWistarTransplantation to dorsal horn1 week after injury (delayed)
Model: Cervical (C7 and C8) dorsal root injury
Delayed OEC transplants attenuated neuropathic pain but did not improve skilled forepaw movements after dorsal root injury.
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RatTBIWeight-drop / impact-accelerationSprague-DawleyTransplantation into the regions surrounding the injured brain siteImmediately after the weight-drop injury
Model: Free weight-drop traumatic brain injury
Transplanted olfactory ensheathing cells survived and migrated around the injury site, significantly improved neurological severity scores, increased GAP-43 immunopositive fibres and synaptophysin-positive vesicles and reduced apoptotic cell numbers, with significant downregulation of Bad (all p <…
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RatSpinal cord injury
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RatSpinal cord injury
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RatSpinal cord injury
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RatSpinal cord injury
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RatSpinal cord injury
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