Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation.
RatBurnScaldSprague-DawleyMalen = At least five animals per experimental group for myeloperox…Intramuscular0.1, 1.0 and 10 mg/kgFirst dose 20 min after burn
Model: 45% total body surface area full-thickness scald burn (dorsum 10 s, abdomen 4 s in 98 to 100 degrees C water) with delayed fluid resuscitation using Hartmann's solution 40 mL/kg intraperitoneally, half at 1 h and half at 8 h after burn
Parecoxib at 1.0 mg/kg reduced plasma CINC-1, interleukin-6 and prostaglandin E2 metabolite and lung myeloperoxidase, gave the least structural organ damage and non-significantly improved 48 h survival (66.6% versus 56.5% for burn controls). Parecoxib at 10 mg/kg lowered circulating cytokines but s…
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