tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury.
RatSpinal cord injuryCompressionWistarFemaleAdministration to the injured spinal cordAfter spinal cord injury
Model: Compression-induced spinal cord injury
Administration of tPA or its downstream effector ADAMTS-4 restored tPA-dependent activity lost after injury, reduced spinal cord chondroitin sulfate proteoglycan content, improved axonal regeneration and sprouting and produced long-term functional recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.