Propranolol impairs the closure of pressure ulcers in mice.
MouseIschaemia-reperfusionOther / unspecifiedMaleTreatment began one day before pressure ulcer induction and continued until eut…
Model: Pressure ulcer induced by two cycles of ischaemia-reperfusion created by external application of two magnetic plates to the skin
Propranolol reduced keratinocyte migration, transforming growth factor-beta expression, re-epithelialisation and necrotic tissue loss, increased neutrophil number and neutrophil elastase, delayed macrophage mobilisation, myofibroblastic differentiation, angiogenesis and wound closure, and produced…
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