Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) c-fibers after spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 81 rats in total: exercise n=27, spinal cord injury alone n…Not applicable, behavioural intervention20 minutes per session, initial speed 5 m/min increasing at…Started 5 days post-injury
Model: Moderate unilateral C5 spinal cord contusion using the Infinite Horizon impactor, 1.6 mm probe, 200 kilodynes, no dwell time, tissue displacement 1600 to 1800 micrometres
Exercise reduced the incidence of tactile allodynia from 42 per cent (10 of 24) in unexercised injured rats to 6 per cent (1 of 17), maintained normal GDNF and artemin levels and prevented IB4-positive afferent sprouting, but had no effect on thermal withdrawal latency or tissue sparing.
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