THERAPY DOSSIER · th-35762056fefd

Forced exercise on automated running wheels

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04340063 ↗Injury indicationNAcompleted

Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury (AGILE SCI) Trial

Incomplete Spinal Cord Injury

Enrolment: 38 · Results not recorded

NCT02703883 ↗Injury indicationNAcompleted

Effects of Body Weight-supported Treadmill Training on Center of Mass Control in Spinal Cord Injury, Measured With Inertial Sensors

Spinal Cord Injury

Enrolment: 17 · Results not recorded

NCT06176833 ↗Injury indicationNArecruiting

Critical Time Window for Rehabilitation After Incomplete Spinal Cord Injury: Early vs Late Locomotor Training

Spinal Cord Injuries

Enrolment: 108 · Results not recorded

NCT03559036 ↗Injury indicationPhase not recordedunknown

Impact of Activity-Dependent Plasticity on Bladder Function After Pediatric Spinal Cord Injury

Spinal Cord Injuries · Neurogenic Bladder

Enrolment: 6 · Results not recorded

NCT06872931 ↗Injury indicationPhase not recordedactive not recruiting

Investigation of the Effects of C-Mill Treadmill Training on Trunk Balance in Patients with Spinal Cord Injury

Spinal Cord Injuries (SCI)

Enrolment: 22 · Results not recorded

NCT03914456 ↗Injury indicationNAcompleted

Assessment of Functional Neurorehabilitation in Spinal Cord Injury Using fMRI and Other Neuroimage Tools

Injuries, Spinal Cord

Enrolment: 7 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24560714 ↗2014Mixed findings

Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) c-fibers after spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 81 rats in total: exercise n=27, spinal cord injury alone n…Not applicable, behavioural intervention20 minutes per session, initial speed 5 m/min increasing at…Started 5 days post-injury

Model: Moderate unilateral C5 spinal cord contusion using the Infinite Horizon impactor, 1.6 mm probe, 200 kilodynes, no dwell time, tissue displacement 1600 to 1800 micrometres

Exercise reduced the incidence of tactile allodynia from 42 per cent (10 of 24) in unexercised injured rats to 6 per cent (1 of 17), maintained normal GDNF and artemin levels and prevented IB4-positive afferent sprouting, but had no effect on thermal withdrawal latency or tissue sparing.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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