Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.

Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.

Model: Peripheral nerve injury-induced neuropathic pain; the specific nerve injury model is not stated in the available text

Genetic deletion or pharmacological inhibition of cathepsin S with Z-FL attenuated the maintenance of tactile allodynia, splenic CD4+ T cell expansion, IFN-gamma positive T cell infiltration of the dorsal spinal cord and microglial proliferation after peripheral nerve injury.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.