THERAPY DOSSIER · th-93ab24e7b855

Cathepsin S inhibitor Z-Phe-Leu-COCHO (Z-FL)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00425321 ↗PHASE2completed

RWJ-445380 cathepsin S inhibitor in active rheumatoid arthritis despite methotrexate

Rheumatoid Arthritis

Enrolment: 259 · Results not recorded

NCT01947738 ↗PHASE1completed

Ascending oral doses of VBY-891 (cathepsin S inhibitor) in healthy subjects

Healthy

Enrolment: 89 · Results not recorded

NCT01911637 ↗PHASE1completed

Single ascending oral doses of VBY-036 (cathepsin S inhibitor) in healthy subjects

Healthy

Enrolment: 48 · Results not recorded

NCT01892891 ↗PHASE1completed

Multiple ascending oral doses of VBY-036 in healthy subjects

Healthy

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24553941 ↗2014Reported benefit

Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state.

MouseOtherC57BL/6 and DBA background, including cathepsin S knockout mice

Model: Peripheral nerve injury-induced neuropathic pain; the specific nerve injury model is not stated in the available text

Genetic deletion or pharmacological inhibition of cathepsin S with Z-FL attenuated the maintenance of tactile allodynia, splenic CD4+ T cell expansion, IFN-gamma positive T cell infiltration of the dorsal spinal cord and microglial proliferation after peripheral nerve injury.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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