Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice.
MouseChemical/toxinSwissMaleOral50 mg/kg; indomethacin comparator 5 mg/kgProphylactic, starting three days before the carrageenan challenge
Model: Carrageenan-induced pleurisy and lung injury: 0.1 mL sterile saline containing 1 per cent carrageenan injected into the pleural cavity at the sixth intercostal space, with analysis 4 hours later
Oral diethylcarbamazine markedly reduced polymorphonuclear cell influx into the pleural cavity, preserved alveolar epithelium and lowered myeloperoxidase, TNF-alpha, IL-1beta, COX-2, iNOS, nitric oxide and NF-kappaB, outperforming indomethacin on cytokine and COX-2 endpoints.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.