Evidence & regulatory context
- Mechanism
- Nematode GABA-A receptor positive modulator (POSITIVE MODULATOR)
- Target
- Nematode GABA-A receptor
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- 1950
- Development stage
- Not recorded
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Camin; Diethylcarbamazine; Dietilcarbamazina; Banocide; Decacide; Difil; Dirocide; Hetrazan; Loxuran; NSC-80513
- Note
- Not recorded
Clinical trials 10
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Safety and Efficacy Trial of Mass Drug Administration With Moxidectin Versus Ivermectin in Combination With Diethylcarbamazine and Albendazole for Lymphatic Filariasis, Scabies, and Strongyloidiasis in Fiji
Lymphatic Filariasis · Scabies · Strongyloidiasis
Enrolment: 5100 · Results not recorded
A Clinical Trial to Assess the Safety and Efficacy of Moxidectin Combination Treatments vs. Ivermectin Combination Treatments for Bancroftian Filariasis
Lymphatic Filariasis
Enrolment: 164 · Results not recorded
A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin
Trachoma · Yaws · Lymphatic Filariases · Scabies · Strongyloidiasis
Enrolment: 20000 · Results not recorded
Evaluate Triple-Drug Therapy With Diethylcarbamize (DEC), Albendazole (ALB) and Ivermectin (IVM) That Could Accelerate LF Elimination Outside of Africa
Lymphatic Filariasis
Enrolment: 182 · Results not recorded
Alternative Chemotherapies for Lymphatic Filariasis (LF) Treatment and Elimination in Africa [Cote d'Ivoire]
Lymphatic Filariasis
Enrolment: 189 · Results not recorded
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Lymphatic Filariasis · Soil Transmitted Helminth Infections
Enrolment: 17108 · Results not recorded
Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) Versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis
Lymphatic Filariasis
Enrolment: 23789 · Results not recorded
Community Based Safety Study of 2-drug Versus 3-drug Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji
Lymphatic Filariases · Scabies · Impetigo
Enrolment: 4773 · Results not recorded
Host Response to Infection and Treatment in the Filarial Diseases of Humans
Filariasis · Helminthiasis · Onchocerciasis
Enrolment: 500 · Results not recorded
Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa
Onchocerciasis · Loiasis
Enrolment: 0 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseChemical/toxinSwissMaleOral50 mg/kg; indomethacin comparator 5 mg/kgProphylactic, starting three days before the carrageenan challenge
Model: Carrageenan-induced pleurisy and lung injury: 0.1 mL sterile saline containing 1 per cent carrageenan injected into the pleural cavity at the sixth intercostal space, with analysis 4 hours later
Oral diethylcarbamazine markedly reduced polymorphonuclear cell influx into the pleural cavity, preserved alveolar epithelium and lowered myeloperoxidase, TNF-alpha, IL-1beta, COX-2, iNOS, nitric oxide and NF-kappaB, outperforming indomethacin on cytokine and COX-2 endpoints.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
