Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord.
RatSpinal cord injuryHemisection / partialInbred strain not specifiedFemaleTransplantation into the hemisection cavity2-7 weeks after injury (chronic lesion)
Model: Lumbar spinal cord hemisection cavity, allowed to become chronic for 2-7 weeks before grafting
Grafts placed into chronic hemisection cavities showed 90% long-term survival and good differentiation. Despite a dense astrocytic scar, foci of confluent host-graft neuropil formed, mainly at host grey matter interfaces. Tract tracing suggested axonal projections into grafts from adjacent host neu…
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