Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (+/-)-Anatoxin A poisoning in rats.
RatChemical/toxinWistar albinoMaleTransdermal, drug-in-adhesive matrix patch applied to shaved dorsal skinPatch applied 72 hours before toxin challenge
Model: (+/-)-Anatoxin A poisoning by subcutaneous injection at 1.0, 1.5 and 2.0 times the LD50, the LD50 being determined as 1.25 mg/kg, causing seizures and acute brain injury with 100 per cent mortality within 5 minutes at 1.0 times LD50
The prophylactic patch prevented seizures, tachycardia, nerve damage, clinical signs, brain injury and mortality after anatoxin A challenge up to a certain multiple of the LD50.
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