THERAPY DOSSIER · th-aa3a8bd841ec

Transdermal patch containing eserine (physostigmine) and pralidoxime chloride

Drug · Acetylcholinesterase inhibitor (mec_id 7605, direct interaction, disease efficacy true)

No trauma translation Suggest a correction

Review required. This record is flagged as borderline.

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Acetylcholinesterase inhibitor (mec_id 7605, direct interaction, disease efficacy true)
Target: CHEMBL220
Injury models: Chemical/toxin
Reported indication: Physostigmine salicylate (Antilirium) approved as an antidote for anticholinergic (antimuscarinic) toxicity and for glaucoma; acute poisoning indication
First approval: Not recorded
Development stage: Approved antidote for acute anticholinergic toxicity; nerve-agent/OP-prophylaxis patch use investigational; niche/old approval
ChEMBL record: CHEMBL94 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Eserine; Eserin; Eserinum; (-)-physostigmine; Cogmine; Antilirium (salicylate, CHEMBL338975)
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03090620 ↗PHASE4completed

Physostigmine vs lorazepam for adolescent antimuscarinic toxidrome

Anticholinergic Toxicity

Enrolment: 19 · Results not recorded

NCT02216266 ↗PHASE3unknown

Physostigmine for treatment of delirium in perioperative intensive care

Delirium after cardiac surgery

Enrolment: 120 · Results not recorded

NCT01394445 ↗PHASE3completed

Influence of physostigmine on patient-controlled analgesia

Postoperative Pain

Enrolment: 20 · Results not recorded

NCT02008292 ↗Phase not recordedcompleted

Acetylcholine, tobacco smoking, genes and nicotinic receptors (physostigmine challenge)

Smoking · Schizophrenia

Enrolment: 80 · Results not recorded

NCT01121497 ↗Phase not recordedunknown

Effect of physostigmine on cognitive functioning after sedation for colonoscopy

Cognitive Dysfunction

Enrolment: 160 · Results not recorded

NCT03013322 ↗Phase not recordedcompleted

Anticholium Per Se: adjunctive physostigmine salicylate in perioperative sepsis and septic shock

Shock, Septic · Sepsis · Perioperative Period

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24530375 ↗2014Reported benefit

Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (+/-)-Anatoxin A poisoning in rats.

RatChemical/toxinWistar albinoMaleTransdermal, drug-in-adhesive matrix patch applied to shaved dorsal skinPatch applied 72 hours before toxin challenge

Model: (+/-)-Anatoxin A poisoning by subcutaneous injection at 1.0, 1.5 and 2.0 times the LD50, the LD50 being determined as 1.25 mg/kg, causing seizures and acute brain injury with 100 per cent mortality within 5 minutes at 1.0 times LD50

The prophylactic patch prevented seizures, tachycardia, nerve damage, clinical signs, brain injury and mortality after anatoxin A challenge up to a certain multiple of the LD50.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

Loading the evidence…