Two-photon-excited fluorescence microscopy as a tool to investigate the efficacy of methylprednisolone in a mouse spinal cord injury model.
MouseSpinal cord injuryCompressionYFP-H line and CX3CR1-GFP transgenic micen = 36 mice in total, 18 YFP-H and 18 CX3CR1-GFP, in three grou…
Model: Compression spinal cord injury following laminectomy
Methylprednisolone improved Basso Mouse Scale recovery at 7 days, increased axonal survival at 72 hours, reduced histological damage and lowered microglial and macrophage proliferation compared with saline-treated injured mice.
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